bulksupplements Sucralose Powder - No Calorie Sweetener What Is Sucralose? Sucralose is a no-calorie sugar substitute that is made by chlorinating sucrose, which selectively combines chlorine with sucrose atoms. Sucralose is a major ingredient in no-calorie sweeteners, such as Splenda®, and is between 300 and 1000 times sweeter than sucrose. Sucralose Benefits Sucralose is a very sweet alternative to sugar and may aid dental health. 0️⃣ NO CALORIE SWEETENER - Sucralose is a no-calorie sweetener that is made by chlorinating sucrose, which selectively combines chlorine with sucrose atoms. Sucralose is a major ingredient in no-calorie sweeteners and is between 300 and 1000 times sweeter than sucrose.